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You are here: Home / AIRR Community / Needs and challenges of biological controls for AIRR-sequencing standardization: an AIRR-C review published in eLife

Needs and challenges of biological controls for AIRR-sequencing standardization: an AIRR-C review published in eLife

July 31, 2021 by Pam Borghardt

Announcing the latest AIRR Community publication!

Adaptive Immune Receptor Repertoire (AIRR) can be deeply analyzed to study its complexity thanks to AIRR-sequencing (AIRR-seq) based on high throughput sequencing. However, like many high-throughput technologies, AIRR-seq comes with several technical challenges, notably the lack of established controls and standards, a necessity when considering current available and envisioned AIRR-seq applications. The Biological Resources Working Group within the AIRR Community, established in 2017, aims at studying, prioritizing and developing biological controls and standardization reagents for AIRR-seq studies. In this article, they review current practices, resources and considerations for using and developing AIRR-seq standards and controls.

Filed Under: Adaptive immune receptor repertoire, AIRR Community, Biological controls Tagged With: Adaptive Immune Receptor Repertoire Community

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AIRR Community News

New episode of the On AIRR podcast is here!

March 25, 2025 By Lorissa Corrie

In this episode of On AIRR, we welcome Dr. Bjoern Peters, Professor at the La Jolla Institute for Immunology, to discuss the crucial role of high-quality data in AI-driven immunological predictions and diagnostics. Dr. Peters shares his journey from theoretical physics to MHC-binding prediction, leading to his work on the Immune Epitope Database (IEDB) — […]

Register now for Zooming into the Community III – A 10th Anniversary AIRR-C Event

March 12, 2025 By Lorissa Corrie

Register Now: May 21 Link and May 22 Link This virtual two-day meeting marks the 10th anniversary of the founding of the AIRR Community. Please join us for a celebration of the AIRR Community and a dive into “Specificity” and what that means via our two scientific sessions and roundtable event. Event outline:   May 21 […]

AIRR Community WG Calls

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Call - Comms & Meetings SC
12:00
Fri, May 16, 2025
Webinar - Zooming into the AIRR Community III
11:00
Wed, May 21, 2025
Webinar - Zooming into the AIRR Community III
11:00
Thu, May 22, 2025
Call - ComRepo WG
11:00
Thu, June 5, 2025
Call - Standards WG
12:00
Thu, June 12, 2025

Recent AIRR Publications

Lees W.D. et al. AIRR Community curation and standardised representation for immunoglobulin and T cell receptor germline sets (Immunoinformatics, 2023)

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